Choose your tower based on what you are doing
Look at a property map before you go and request a room location based on what you are doing. For example, the North Wing is great for the show KA, conventions and the pool. Choose the South Wing for David Copperfield or if you plan on leaving in a taxi often. Finally, the West Wing is convenient if you plan on walking the strip - there is an exit to the strip right off the elevator. Unfortunately, the Signature Towers is about a 10 minute walk to anything, but they do have their own pools.